<p>Iga Swiatek will be aiming to win back-to-back Grand Slams <a href="https://www.sportsbet.com.au/huddle/tennis/predictions/2025-us-open-tennis-betting-preview-odds">in the upcoming 2025 US Open</a>, having won at Wimbledon in the British summer.</p> <p>She will face plenty of stern competition at the USTA Billie Jean King National Tennis Center when the competition begins on August 24 (AEST TBD). However, bettors might like her chances after winning the Cincinnati Open at the beginning of the week.</p> <p>With a $5,000,000 (approx. AUD$7,765,422) on offer to the winner, will she claim another huge winner’s cheque, or will someone else take the final major of the year?</p> <h2>US Open Women’s Singles 2025 Betting Preview</h2> <p>The winner of the last two Cincinnati Open tournaments in the women’s singles has gone on to win the US Open a few weeks later. Coco Gauff won in 2023 before winning at Flushing Meadows for her second Grand Slam victory, while Aryna Sabalenka won last year before winning the event.</p> <p>Swiatek will be hoping that trend continues this year, although she does have a previous success in this tournament. She won the US Open in 2022 and has six Grand Slam titles to her name. While her form had dipped before Wimbledon, she has regained it and is a formidable opponent.</p> <p>Still, those two names mentioned above cannot be discredited in the betting.</p> <p>Sabalenka is the world’s&nbsp; number 1 player and defending champion. She may not be in the best form at the moment, but she does thrive on hard courts with her dominant serve and power baseline game. She’s reached the final or semis in five of the last six Grand Slams, making her a strong favourite in the betting.</p> <p>Gauff has prior success and won a Grand Slam this year, having been victorious over Sabalenka on the clay courts of the French Open. She will be backed at home. If there are any doubts, it’s because she’s struggled for hard-court consistency this year.</p> <h2>US Open Women’s Singles 2025 Betting Predictions</h2> <p>Sabalenka and Swiatek are co-favourites to win in the latest <a href="https://www.sportsbet.com.au/betting/tennis/ladies-us-open">2025 US Open Women’s singles betting odds</a>, with Gauff behind them. It’s hard to disagree with these odds, but there’s value when looking at a possible each-way bet (a player reaching the final).</p> <p>Mirra Andreeva and Elena Rybakina could both be worth a shot, as they’ve been good this year. Andreeva may only be 18, but she made multiple Slam quarter-finals in 2025. She continues to make improvements in her game, which has upset players ranked above her in the past.</p> <p>Rybakina is another with potential. A winner at Wimbledon in 2022, Rybakina boasts a big serve, flat groundstrokes, and thrives under pressure. Her hard-hitting style makes her a threat, as Sabalenka found out during her defeat in Cincinnati in the quarter-finals.</p>