<p>Italian soccer has always been widely enjoyed, and with a strong following in Australia, its return will be welcomed by many bettors because of the opportunities that can be available.</p> <p>We previewed the upcoming campaign, focusing on <a href="https://www.sportsbet.com.au/huddle/soccer/tips-predictions-soccer/serie-a-betting-predictions-tips">who might be crowned the next Scudetto champion</a>, with Napoli expected to be in the running once again. However, an injury to Romelu Lukaku might put Antonio Conte’s side in a difficult position to begin the campaign.</p> <p>Nonetheless, they won’t be able to dwell on that too much, with the season kicking off this weekend. Let’s take a look at what those fixtures are and try to find some top Serie A betting predictions to sink your teeth into…</p> <h2>Serie A 2025/26 Matchweek 1 Betting Preview</h2> <p>The opening weekend of fixtures will see many quality soccer fixtures take place. The following have been scheduled to take place…</p> <ul> <li>Genoa vs Lecce (Sunday, 02:30 AEST)</li> <li>Sassuolo vs Napoli (Sunday, 02:30 AEST)</li> <li>Roma vs Bologna (Sunday, 04:45 AEST)</li> <li>Milan vs Cremonese (Sunday, 04:45 AEST)</li> <li>Cagliari vs Fiorentina (Monday, 02:30 AEST)</li> <li>Como vs Lazio (Monday, 02:30 AEST)</li> <li>Juventus vs Parma (Monday, 04:45 AEST)</li> <li>Atalanta vs Pisa (Monday, 04:45 AEST)</li> <li>Udinese vs Verona (Tuesday, 02:30 AEST)</li> <li>Inter vs Torino (Tuesday, 04:45 AEST)</li> </ul> <h2>Serie A 2025/26 Matchweek 1 Betting Predictions</h2> <p>We have a host of <a href="https://www.sportsbet.com.au/betting/soccer/italy/italian-serie-a">2025/26 Serie A betting odds</a> available this season, making it easy for you to place a bet on the soccer that takes place in this league with Sportsbet.</p> <p>Ahead of the opening weekend, we’ve taken a look at some of the matches scheduled to make our predictions on what we think could happen and may represent value in the betting odds.</p> <p>The opening day <a href="https://www.sportsbet.com.au/betting/soccer/italy/italian-serie-a/genoa-v-lecce-9301750">Genoa vs Lecce</a> contest may offer bettors value in terms of the goal markets. Genoa are strong at home and showed good preseason form. Lecce are competitive, but H2H heavily favours Genoa (won 3 of last 4 at home vs Lecce). However, backing the ‘Yes’ in the ‘Both Teams to Score’ market could work, as it has hit in each of Genoa's last five Serie A Week 1 home matches.</p> <p>The <a href="https://www.sportsbet.com.au/betting/soccer/italy/italian-serie-a/ac-milan-v-us-cremonese-9301684">AC Milan vs Cremonese betting odds</a> lean strongly in the hosts’ favour, which is no surprise. Where value might be possible to obtain in this game is in the ‘Win to Nil’ market. Milan’s odds look favourable, and with the visitors recently promoted to Serie A, it wouldn’t be a surprise if Massimiliano Allegri’s stars kept a clean sheet here.</p> <p><a href="https://www.sportsbet.com.au/betting/soccer/italy/italian-serie-a/como-v-lazio-9301685">Como vs Lazio</a> is an intriguing bet. Como have just been promoted to Italy’s top-flight, while Lazio are an established team. The odds are actually favouring the home side, but with Lazio’s experience, it could be worth backing the visitors to win this one.</p>