<p>With Matchweek 16 of the English Premier League about to take centre stage, many across the division will be feeling the pressure.</p> <p>Last weekend saw several unexpected results and poor performances occur.<strong> Arsenal</strong> and <strong>Chelsea</strong> both dropped points in MW15, while <strong>Man City</strong> had a routine victory. <strong>Liverpool </strong>dropped points once again as the pressure mounts on <strong>Arne Slot</strong>, with an explosive interview from<strong> Mohamed Salah</strong> after the game not helping.</p> <p>Read on for our top Premier League 2025/26 Matchweek 16 betting predictions…</p> <h2>Premier League 2025/26 Matchweek 16 Betting Preview</h2> <p>The matches scheduled for MW16 are:</p> <ul> <li>Chelsea vs Everton (Sunday, December 14, 02:00 AEDT)</li> <li>Liverpool vs Brighton (Sunday, December 14, 02:00 AEDT)</li> <li>Burnley vs Fulham (Sunday, December 14, 04:30 AEDT)</li> <li>Arsenal vs Wolves (Sunday, December 14, 07:00 AEDT)</li> <li>Crystal Palace vs Man City (Monday, December 15, 01:00 AEDT)</li> <li>Sunderland vs Newcastle (Monday, December 15, 01:00 AEDT)</li> <li>Nottingham Forest vs Tottenham (Monday, December 15, 01:00 AEDT)</li> <li>West Ham vs Aston Villa (Monday, December 15, 01:00 AEDT)</li> <li>Brentford vs Leeds (Monday, December 15, 03:30 AEDT)</li> <li>Man Utd vs Bournemouth (Tuesday, December 16, 07:00 AEDT)</li> </ul> <p>Several storylines exist in the games this weekend; <strong>Chelsea</strong> will face a team that they’ve struggled against at times in <strong>Everton, Arsenal </strong>will aim to keep their advantage at the top against winless Wolves, and <strong>Man City</strong> take on <strong>Crystal Palace</strong> in a tricky encounter. At the same time,<strong> Liverpool</strong> have a tough home game against<strong> Brighton</strong> and are likely to be without <strong>Salah</strong>.</p> <p>The biggest game of the weekend is arguably the<strong> Tyne-Wear derby</strong>, with<strong> Sunderland hosting Newcastle</strong> for the first time in the Premier League for almost 10 years. That time, it ended 1-1.</p> <h2>Premier League 2025/26 Matchweek 16 Betting Predictions</h2> <p>Here are our top MW16 predictions with our <a href="https://www.sportsbet.com.au/betting/soccer/united-kingdom/english-premier-league">2025/26 Premier League betting odds and markets</a>, keeping in mind everything we mentioned above:</p> <ul> <li><strong><a href="https://www.sportsbet.com.au/betting/soccer/united-kingdom/english-premier-league/crystal-palace-v-man-city-9915068">Crystal Palace vs Man City</a></strong> - <strong>City are the big favourites</strong> entering the game;<strong> Guardiola’s</strong> side are unbeaten in their last three at Selhurst Park in the EPL with two victories.<strong> ‘Over 2.5 Goals’ </strong>looks good value based on previous meetings.</li> <li><strong><a href="https://www.sportsbet.com.au/betting/soccer/united-kingdom/english-premier-league/liverpool-v-brighton-9915018">Liverpool vs Brighton</a> </strong>- <strong>Liverpool big favourites</strong>, but they’re under pressure. Positive UCL results haven’t followed in the EPL this season as Slot remains in trouble.<strong> Brighton as the underdog</strong> looks good value, as Liverpool has lost three of its last four EPL day matches as a favourite.</li> <li><strong><a href="https://www.sportsbet.com.au/betting/soccer/united-kingdom/english-premier-league/sunderland-v-newcastle-9915107">Sunderland vs Newcastle</a></strong> - <strong>Newcastle are in a good run of form</strong>, and we predict they will edge this one. The <strong>'Both Teams to Score'</strong> market has hit in each of Newcastle United's last eight EPL matches, making the ‘<strong>Yes</strong>’ offer good value. Additionally, ‘<strong>Bruno Guimarães - To Score Or Assist</strong>’ looks good, as he has scored or assisted in three of the last four EPL matches.</li> </ul>