Arsenal are the defending champions and will look to ensure they have a good chance of keeping their hopes alive when they meet in the first leg on Monday, April 27, at 01:30 AEST.

Quick Picks

Our pick: Lyon to win

Value bet: Russo to score anytime

Long shot: 'Over' in the '1st Half Over/Under 1.5 Goals'

Betting Preview

Arsenal secured their place in the Last Four by defeating Chelsea in the previous round. Despite losing the second leg 1-0 at Stamford Bridge, Renée Slegers's side managed to do the hard work at home in the first leg, winning 3-1.

Alessia Russo has been exceptional in this year's competition, leading the goal-scoring charts with eight goals.

She netted in the 1st leg encounter against Chelsea, giving them the all-important goal that gave them the advantage that they would eventually need to get through.

Lyon have had to work hard to reach this stage of the competition, although they've continued to show why many still consider them among the best teams in women's club soccer.

They managed to overturn a 1-0 deficit in their quarter-final tie against Werder Bremen by winning 4-0 in the second leg.

What was perhaps more impressive was that they managed to score three in extra time to secure passage to the semi-final, having only managed to score once in the first 90 minutes.

Lyon were exceptionally aggressive in that game, totalling 32 shots on goal (13 on target).

Betting Markets to Watch

The early soccer betting odds are close, with neither team being considered a sure favourite to win. This is why we think there's better value available in alternative markets to the moneyline.

We think there could be value in the 1st Half Over/Under 1.5 Goals market, with the over hitting. Both teams have shown in this year's tournament that they can be aggressive when attacking, with goals often being found in the first 45 minutes.

Lyon did this in their last game, whereas Arsenal didn't. However, both will want to get on the front foot first and try to take advantage of the first leg.

Russo offers good value as an anytime goalscorer, while Melchie Dumornay could also offer value. She has five so far in this year's tournament, including one in the 4-0 win against Werder Bremen.

Our Prediction

Check the latest Arsenal (W) vs Lyon (W) betting odds at Sportsbet.

We think Lyon are the most likely to win this game. They have been impressive in recent games, and could have too much for Arsenal.

With Lyon's ability to attack and be strong, as well as Arsenal's potency, we think there's value in the 'Over 3.5 goals' market, too.