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NFL Week 2 Prediction and Betting Odds

SB Staff|18/09/2026|
NFL week 2 predictions

 

The Seattle Seahawks started their Super Bowl defence with a win, while Australia hosted its first-ever game when the Los Angeles Rams and San Francisco 49ers met in Melbourne.

With the sport growing locally, it is worth bookmarking our guide on how to watch the Super Bowl in Australia for later in the season.

Now, it’s time for Week 2 of the regular season, with many aiming to build on their first win, while others are looking to get theirs…

 

Quick Picks

 

Our pick: Seahawks to win

Value bet: Colts leading at HT

Long shot: Giants to win

 

Betting Preview

 

Full Week 2 fixtures are as follows (all KO AEST); games in bold are divisional games:

 

 

Betting Markets to Watch

 

Seattle put on a real show in their first game since winning the Super Bowl, and are big favourites to beat the Cardinals.

On an 11-game run, the most value in this game comes from their handicap, as the Seahawks have covered the line in each of their last six games when playing with a rest advantage.

Dallas and Washington play their second NFC East divisional game in back-to-back weeks after both losing their opener. This one favours Dallas; they’ve won each of their last 12 games as home favourites against NFC East opponents.

The ‘Over Total Match Points’ has value, as each of the Commanders' last six games against NFC East opponents have.

Kansas City are strong favourites to beat Indianapolis following Patrick Mahomes’ return to the field and impressive performance last week.

The value could be in the Colts winning at HT. The road team has won the first half in seven of the last eight games between the Colts and Chiefs.

Arguably the tie of the week, the Giants versus Rams matchup is an interesting one. New York looked impressive against Dallas under John Harbaugh, with Jaxson Dart playing a clean game.

As we predicted, the Rams are coming off the back of a defeat against the 49ers in Australia and could be without Aaron Donald and Myles Garrett.

The Rams are big favourites, but we think there’s value in the Giants given last week’s efforts and the adjustments the Rams may need to make.

 

Our Prediction

 

You can check out our latest NFL betting odds.

Our main prediction is for Seattle to win, with the value in the Colts to be winning at HT against the Chiefs.

Our long shot is the Giants to beat the Rams; they’ve lost their last 12 road games as underdogs, but there’s new life in Big Blue that makes them interesting given their value.

Cincinnati Bengals
Houston Texans

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