<p><em>&nbsp;Both enjoyed a contrasting start, as Scotland were upset by Italy, while England thrashed Wales.</em></p> <p>Scotland will have been shocked by their defeat in Rome, having entered that game on the back of winning four of the last five Six Nations meetings between them. It was a close game, with Italy edging it 18-15.</p> <p>England had no such concerns last weekend, as they thumped Wales 48-7 to kick-start their Six Nations campaign. Now, the two arch-rivals will take to Murrayfield in what is likely to be a fierce contest.</p> <p>Read on for our Scotland vs England <a href="https://www.sportsbet.com.au/betting/rugby-union/the-six-nations">Six Nations betting</a> predictions…</p> <h2>Quick Picks</h2> <p><strong>Our pick: </strong>England to win</p> <p><strong>Value bet: </strong>Scotland cover +7.5 points line</p> <p><strong>Long shot: </strong>'Under +22.5' points in the 1st half</p> <h2>Betting Preview</h2> <p>As noted, Scotland would have expected to have overcome Italy based on their positive record heading into that game. They also have a positive record against England over recent Six Nations campaigns, but is that going to benefit them?</p> <p>England are unbeaten in their last 12 matches across all competitions, last experiencing defeat in Feb 2025 against Ireland. That does include a one-point victory over Scotland, but in general, they've dominated whoever has been in front of them.</p> <p>So, what about the recent head-to-head between the two nations? Games have been close and Scotland have enjoyed the rub of the green in recent years. Results have included:</p> <ul> <li>Feb 2025: England 16-15 Scotland</li> <li>Feb 2024: Scotland 30-21 England</li> <li>Feb 2023: England 29-23 Scotland</li> <li>Feb 2022: Scotland 20-17 England</li> <li>Feb 2021: England 6-11 Scotland</li> <li>Feb 2020: Scotland 6-13 England</li> </ul> <p>As we can see, games are relatively close between these two nations, with Scotland appearing to hold an edge.</p> <h2>Betting Markets to Watch</h2> <p>Given the recent form that England have been showing, as well as the enjoyment that Scotland have had over the last six, we think that there is value in the line market.</p> <p>We think it's likely that Scotland covers the +7.5 line that has been set, as we think it is likely that we'll see a close encounter between the two teams and one that England wins. Over the last six, there has only been one game that has seen a margin greater than eight points.</p> <p>When looking for additional value, we think that the 'Under 46.5' in the total points market offers value. Again, games are often close and don't feature huge totals. This number has only been passed twice over the last six, meaning two-thirds of the time the total has been 37 or fewer.</p> <h2>Our Prediction</h2> <p>Check the latest <a href="https://www.sportsbet.com.au/betting/rugby-union/the-six-nations/scotland-v-england-10135602">Scotland vs England betting odds</a> at Sportsbet.</p> <p>Our prediction is that<strong> England will be the likely winners</strong> of this contest. We think that their form heading into this game (12 unbeaten) will be too much for Scotland to handle, especially after a surprise defeat to Italy last weekend.</p> <p>For a long shot, we think the<strong> 'Under +22.5' points in the 1st half </strong>offers good value. With games typically tight, we think that this game could follow the pattern of previous meetings.</p> <p>For those looking to <a href="https://www.sportsbet.com.au/betting/rugby-union/international-matches">bet on international rugby</a>, this Calcutta Cup clash promises to be one of the highlights of the round.</p> <h2>Keep Reading</h2> <ul> <li><a href="https://www.sportsbet.com.au/huddle/punter-iq/guide/how-to-bet-rugby-championship">How to approach southern hemisphere rugby betting like a seasoned punter</a></li> <li><a href="https://www.sportsbet.com.au/betting/rugby-union/european-champions-cup">Who's in the hunt to be crowned kings of European club rugby?</a></li> <li><a href="https://www.sportsbet.com.au/">Your home for all the latest sports betting markets</a></li> </ul>