<p>When the Premier League action returns at the weekend, there aren’t many bigger games than the one between Manchester United and Chelsea on Sunday, September 21, at 02:30 AEST.</p> <p>Both clubs have a storied rivalry, and one that can be heated at times. It’s an encounter that often offers plenty of drama, including an incredible meeting in 2024 at Stamford Bridge that saw the hosts triumph in the final few minutes.</p> <p>And with a game of this magnitude set to take place, there’s plenty of betting angles to consider this upcoming weekend…</p> <h2>Man Utd vs Chelsea Betting Preview</h2> <p>A quick look at the last five meetings between these two clubs can provide an insight into what to expect:</p> <ul> <li>Chelsea 1-0 at Stamford Bridge</li> <li>1-1 at Old Trafford</li> <li>Chelsea 4-3 at Stamford Bridge</li> <li>Man Utd 2-1 at Old Trafford</li> <li>Man Utd 4-1 at Old Trafford</li> </ul> <p>Indeed, the recent form appears to favour the Red Devils in this contest. However, it’s difficult to trust what Ruben Amorin’s side will do due to inconsistency. Additionally, Enzo Maresca appears to be getting the best out of his young Chelsea squad.</p> <p>Contrasting form has been experienced at the beginning of the 2025/26 EPL campaign. United are currently 14th with one win and one draw from four games, while Chelsea are fifth with two wins and two draws from four.</p> <p>While there have been quite a few transfers between the two clubs in the past, Alejandro Garnacho’s this past transfer window is one that may catch the attention of bettors. The Argentine switched Manchester for London and has made just one cameo appearance in the league so far, but it was impressive. Could he get more minutes in this one? And if he does, will he have a similar impact as he did in the last EPL game?</p> <p>Cole Palmer scored a goal on his return at the weekend, while João Pedro continues to enjoy life in London since his switch from Brighton.</p> <h2>Man United vs Chelsea Betting Predictions</h2> <p>The latest <a href="https://www.sportsbet.com.au/betting/soccer/united-kingdom/english-premier-league/man-utd-v-chelsea-9575958">Man United vs Chelsea betting odds</a> have the London outfit as the favourites heading into this contest, although they are only edging the betting. It’s worth remembering that they have faced Bayern earlier in the week as part of their Champions League campaign. Man United, meanwhile, will be rested.</p> <p>Given the point he may feel he needs to prove, Garnacho as an ‘Anytime Goalscorer’ could be a good value bet to make. In addition, João Pedro could also be worth backing, as he has two goals (three assists) in his first four Premier League matches for Chelsea.</p> <p>The ‘Over 2.5 Goals’ also looks to be worth betting value, as it has hit in three of the last five matches between the two teams. With both inconsistent at the back, United perhaps more so than Chelsea, goals may be free-flowing once again.</p>