<p>Novak Djokovic is set to face Lorenzo Musetti in a blockbuster<a href="https://www.sportsbet.com.au/betting/tennis/mens-australian-open/men-s-australian-open-winner-2026-8896398"> Australian Open</a> quarter-final on Wednesday, with history and momentum firmly on his side.</p> <p>As Djokovic chases his 11th Aussie Open title, all eyes are on whether he can extend his dominance in Melbourne or if Musetti can pull off a tournament-defining upset.</p> <p>Already the first player to win 400 matches at a major, Djokovic is gunning for an unprecedented 11th Australian Open crown. He’s now reached the quarters for a record 16th time at Melbourne Park, surpassing the great Roger Federer.</p> <p>In the process of breaking this record, Djokovic has barely put a foot wrong, dropping just one set all tournament and winning 77% of first serves in his last completed match.</p> <p>His serve has clocked up to 204 km/h, and he’s committed just 23 errors in his most recent outing. Meaning the only thing hotter than the Serbian superstar at the moment is the Melbourne weather.</p> <p>On the other side of the net, this is Musetti’s first foray into the Australian Open quarterfinals, with the Italian securing a date with the last eight after dispatching Taylor Fritz in straight sets.</p> <p>Musetti’s serve has been firing at a peak of 213 km/h, and he’s won 84% of first serves and 73% of net points in his last match.</p> <p>Unsurprisingly, Djokovic leads their head-to-head rivalry convincingly, with Musetti’s only win coming on clay in Monte Carlo 2023.</p> <p>On hard courts and at Grand Slams, Djokovic has been near untouchable against the Italian.</p> <p>Djokovic cruised through the early rounds and benefited from a walkover in the last 16, meaning he will be fresher than usual here. Meanwhile Musetti has had to battle through a couple of five-setters but looked sharp against Fritz.</p> <p>Can the young Italian hold his own against the undisputed King of Melbourne Park? Let’s find out. For all the latest betting tips and analysis, check out our Novak Djokovic vs Lorenzo Musetti preview and prediction below.</p> <p>&nbsp;</p> <h2>Djokovic vs Musetti Betting Tips</h2> <p>&nbsp;</p> <h3>Match Betting</h3> <p>When it comes to head-to-head betting, Novak Djokovic is the clear favourite, and for good reason.</p> <p>The Serbian’s record at Melbourne Park is legendary, and his current form suggests he’s peaking at just the right time. Not only has he dominated Musetti in previous encounters (winning all but one), but he’s also far fresher, having had a walkover in the last 16 and spending less time on court overall.</p> <p>Musetti, while talented and enjoying a breakthrough run, has never beaten Djokovic on a hard court.</p> <p>The Italian’s serve and net play have been impressive, but he’ll need to maintain near-perfect tennis to trouble the 10-time champion.</p> <p>Djokovic’s superior experience, mental toughness, and proven stamina at this stage of the tournament make him the logical pick.</p> <p><strong>Betting tip:</strong>&nbsp;<a href="https://www.sportsbet.com.au/betting/tennis/mens-australian-open/lorenzo-musetti-v-novak-djokovic-10087504">Novak Djokovic.</a></p> <p>&nbsp;</p> <h3>Set Betting</h3> <p>Looking at the set betting market, the most likely scenario appears to be Djokovic winning in four sets. Musetti has shown enough quality, particularly with his serve and shot making, to suggest he can snatch a set, as he did in their 2024 French Open clash.</p> <p>However, Djokovic’s ability to adjust and raise his level in the big moments should see him take control after any early resistance.</p> <p>A straight sets win for Djokovic isn’t out of the question in our opinion, but Musetti’s form and confidence make a 3-1 scoreline seem like the value play to us.</p> <p><strong>Betting tip:</strong>&nbsp;<a href="https://www.sportsbet.com.au/betting/tennis/mens-australian-open/lorenzo-musetti-v-novak-djokovic-10087504">Djokovic – 3-1.</a></p> <p>&nbsp;</p> <h3>Total Match Games</h3> <p>The total games line is likely to sit around the mid-to-high 30s, reflecting expectations of a competitive four-setter. Given our prediction of Djokovic in four, with Musetti able to keep sets close but not push it to five, the total should edge towards, but possibly not exceed, the line.</p> <p>Expect at least one tight set and a handful of breaks, but Djokovic’s ability to close out sets efficiently keeps this from blowing out.</p> <p><strong>Betting tip:</strong>&nbsp;<a href="https://www.sportsbet.com.au/betting/tennis/mens-australian-open/lorenzo-musetti-v-novak-djokovic-10087504">Under total match games.</a></p> <p>&nbsp;</p> <h2>Where to Watch the Djokovic vs Musetti Australian Open Match?</h2> <p>&nbsp;</p> <p>For those in Australia, you can watch the 2025 Men’s Australian Open Quarter-Final between Novak Djokovic and Lorenzo Musetti on the Nine Network.</p> <p>Available on both free-to-air on Channel 9, and 9Gem, you can also watch the match online on 9Now.</p> <p>Alternatively, you can stream the Men’s AO Quarter-Final on streaming service Stan Sport.</p>